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15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide |
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| Authors: | Alexandra Svyatova Dr Ivan V Skovpin Dr Nikita V Chukanov Dr Kirill V Kovtunov Prof Eduard Y Chekmenev Dr Andrey N Pravdivtsev Prof Jan-Bernd Hövener Prof Igor V Koptyug |
| Institution: | 1. International Tomography Center, SB RAS, 3A Institutskaya st., Novosibirsk, 630090 Russia
Novosibirsk State University, 2 Pirogova st., Novosibirsk, 630090 Russia;2. International Tomography Center, SB RAS, 3A Institutskaya st., Novosibirsk, 630090 Russia;3. Department of Chemistry, Wayne State University, Karmanos Cancer Institute (KCI), Integrative Biosciences (Ibio), Detroit, MI 48202 USA Russian Academy of Sciences (RAS), 14 Leninskiy Prospekt, Moscow, 119991 Russia;4. Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology University Medical Center Schleswig-Holstein (UKSH), Kiel University, Am Botanischen Garten 14, 24118 Kiel, Germany |
| Abstract: | Magnetic Resonance Imaging (MRI) is a powerful non-invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal-to-noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized 15N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio-frequency-based SABRE hyperpolarization techniques can be used to obtain 15N MRI of biomolecule 1-15N-nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high-field SABRE for biomedical applications. |
| Keywords: | 15N MRI hyperpolarization molecular imaging parahydrogen SABRE |