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Polyoxygenated Tertiary Alcohols: A Kiyooka Approach |
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| Authors: | Daniel Lücke Prof Dr Markus Kalesse |
| Institution: | 1. Institute for Organic Chemistry, Gottfried Wilhelm Leibniz Universität Hannover, 30167 Hannover, Germany
Centre of Biomolecular Drug Research (BMWZ), Gottfried Wilhelm Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany;2. Institute for Organic Chemistry, Gottfried Wilhelm Leibniz Universität Hannover, 30167 Hannover, Germany |
| Abstract: | A Kiyooka aldol approach for the stereoselective synthesis of tertiary alcohols is presented. This approach allows for the incorporation of different substituents at all three remaining positions at the chiral center bearing the tertiary alcohol. To demonstrate the validity of this approach different chiral alcohols were depicted and the relationship of double bond geometry of the ketene acetal and the diastereoselectivity was established. |
| Keywords: | aldol reaction chiral aldehydes double bond geometry ketene acetal structure elucidation |