Cationic Chalcogenoviologen Derivatives for Photodynamic Antimicrobial Therapy and Skin Regeneration |
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| Authors: | Kun Zhou Ran Tian Guoping Li Xinyu Qiu Letian Xu Mengying Guo Dongdong Chigan Prof Dr Yanfeng Zhang Prof Dr Xin Chen Prof Dr Gang He |
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| Institution: | 1. Frontier Institute of Science and Technology, State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry, Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710054 China;2. School of Chemical Engineering and Technology, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710054 China;3. Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi Province, 710032 China |
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| Abstract: | A series of water-soluble cationic chalcogenoviologen-based photosensitizers for photodynamic antimicrobial therapy (PDAT) is reported. The Se-containing derivatives (SeMV2+) 5 b and 6 b showed good antimicrobial activities due to the presence of chalcogen atoms and a cationic scaffold. The former efficiently enhanced the generation of reactive oxygen species (ROS), and the latter facilitated the ROS delivery to bacteria, resulting in their death. Interestingly, alkyl-modified photosensitizers showed higher antimicrobial activities than commonly reported photosensitizers with quaternary ammonium (QA) groups. In particular, the SeMV2+ ( 6 b ) with excellent antibacterial activities efficiently promoted the healing of infected wounds in mice. Simple yet novel, nontoxic and biocompatible chalcogenoviologens provided a promising strategy to develop new efficient photosensitizers for photodynamic antimicrobial therapy and skin regeneration. |
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| Keywords: | antibiotics cationic chalcogenoviologens membrane intercalating agents photodynamic antimicrobial therapy skin regeneration |
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