Two-Photon-Induced CO-Releasing Molecules as Molecular Logic Systems in Solution,Polymers, and Cells |
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| Authors: | Dr. Vadde Ramu Dr. Gandra Upendar Reddy Dr. Jingjing Liu Patrick Hoffmann Dr. Rudrakant Sollapur Dr. Ralf Wyrwa Dr. Stephan Kupfer Prof. Dr. Christian Spielmann Dr. Sylvestre Bonnet Prof. Dr. Ute Neugebauer Dr. Alexander Schiller |
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| Affiliation: | 1. Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, 07743 Jena, Germany;2. Center for Sepsis Control and Care (CSCC), Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany;3. Institute of Optics and Quantum Electronics, Friedrich Schiller University Jena, Max Wien Platz 1, 07743 Jena, Germany;4. INNOVENT e.V., Biomaterials Department, Prüssingstraße 27B, 07745 Jena, Germany;5. Institute for Physical Chemistry (IPC) and Abbe Center of Photonics (ACP), Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany;6. Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, 2300 RA, Leiden, The Netherlands |
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| Abstract: | Phototherapeutic applications of carbon monoxide (CO)-releasing molecules are limited because they require harmful UV and blue light for activation. We describe two-photon excitation with NIR light (800 nm)-induced CO-release from two MnI tricarbonyl complexes bearing 1,8-naphthalimide units ( 1 , 2 ). Complex 2 behaves as a logic OR gate in solution, nonwovens, and in HeLa cells. CO release, indicated by fluorescence enhancement, was detected in solution, nonwoven, and HeLa cells by single- (405 nm) and two-photon (800 nm) excitation. The photophysical properties of 1 and 2 have been measured and supported by DFT and TDDFT quantum chemical calculations. Both photoCORMs are stable in the dark in solution and noncytotoxic, leading to promising applications as phototherapeutics with NIR light. |
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| Keywords: | immobilization logic gates low cytotoxicity nonwoven fabric materials two-photon CORMs |
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