酶促聚合与ATRP结合合成聚己内酯和聚N,N-二甲氨基甲基丙烯酸乙酯嵌段共聚物及其自组装

摘要：用化学酶法合成聚己内酯（PCL）和聚N,N-二甲氨基甲基丙烯酸乙酯（PDMAEMA）双亲嵌段聚合物（PCL-b-PDMAEMA）。通过核磁共振（1H NMR）,红外光谱仪(FTIR-IR),凝胶渗透色谱(GPC) 对其结构以及分子量与其分子量分布情况进行了表征。对聚合物的溶液性质进行了研究，结果表明：临界胶束浓度（CMC）嵌段聚合物中疏水链段增多有利于形成胶束，表现为CMC降低，并具有较高的热力学稳定性。PDMAEMA是PH和温度敏感材料，研究发现,在不同的温度和pH值条件下表现不同的聚集状态, 当聚合物的pH值降低时平均流体力学直径增加，温度升高平均流体力学直径降低。

Synthesis of Amphiphilic Block Copolymer PCL-b-PDMAEMA by the Combination of Enzymatic-promoting Polymerization with ATRP and Its Self-assembly Behavior

Amphiphilic poly(caprolactone)-block-poly(dimethylaminoethyl methacrylate)(PCL-b-PDMAEMA) was synthesized by the combination of enzymatic-promoting polymerization with atom transfer radical po-lymerization.The structure of the diblock polymers was characterized by GPC,1H NMR and FITR.Dynamic light scattering(DLS) was used to study the self-assembly behavior in water solution,and the response of pH and temperature dependence was preliminarily investigated.