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Ligand-free Sonogashira coupling reactions with heterogeneous Pd/C as the catalyst |
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| Authors: | Mori Shigeki Yanase Takayoshi Aoyagi Satoka Monguchi Yasunari Maegawa Tomohiro Sajiki Hironao |
| Affiliation: | Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 6-1, Mitahora-higashi 5-chome, Gifu, Japan. |
| Abstract: | A variety of aryl iodides were coupled with aromatic and aliphatic terminal alkynes to give the corresponding 1,2-disubstituted aromatic alkynes in good yields by using only 0.4 mol % of the heterogeneous 10 % Pd/C as the catalyst without a ligand, copper salt, or amine in an aqueous medium. |
| Keywords: | alkynes C?C coupling environmental chemistry heterogeneous catalysis palladium |
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