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T3P®-DMSO mediated one pot cascade protocol for the synthesis of 4-thiazolidinones from alcohols |
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| Authors: | Kothanahally S Sharath KumarToreshettahally R Swaroop Kachigere B HarshaKereyagalahally H Narasimhamurthy Kanchugarakoppal S Rangappa |
| Institution: | Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India |
| Abstract: | Propylphosphonic anhydride (T3P®)-DMSO mediated oxidation of alcohols to carbonyl compounds and their subsequent cyclization with aryl/hetero aryl amines and thioglycolic acid to afford 4-thiazolidinones has been reported. Synthesis of 4-thiazolidinones directly from alcohols has been carried out for the first time. Mild reaction conditions, wide functional group tolerance, ease of work-up, and good yields are the noteworthy features of this protocol. |
| Keywords: | Propylphosphonic anhydride (T3P® ) Cascade 4-Thiazolidinones Thioglycolic acid (or mercaptoacetic acid) |
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