An efficient sequential one-pot base mediated C-O and Pd-mediated C-C bond formation: synthesis of functionalized cinnamates and isochromenes |
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Authors: | A Gopi Krishna ReddyJ Krishna G Satyanarayana |
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Institution: | Department of Chemistry, Indian Institute of Technology (IIT) Hyderabad, Ordnance Factory Estate Campus, Yeddumailaram 502 205, Medak District, Andhra Pradesh, India |
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Abstract: | An efficient sequential one-pot intermolecular oxy-Michael addition and intermolecular Heck coupling for the synthesis of functionalized cinnamates is presented. Bulky tert-butyl acrylate was identified as a more suitable Michael acceptor for initial oxy-Michael addition, as it precludes the formation of undesired cross condensed ester. Most importantly, the present method was further divergently extended to the successful synthesis of isochromenes via a sequential one-pot O-allylation and subsequent intramolecular Heck cyclization. |
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Keywords: | Oxy-Michael addition Heck coupling Pd-catalysis Cinnamates Isochromenes |
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