Reactivity of the -C(Cl)C-CN- moiety towards AlCl3-induced C-C bond forming reactions: a new synthesis of 7-(hetero)aryl-substituted pyrazolo[1,5-a]pyrimidines |
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| Authors: | Arumugam Kodimuthali Nishad T. C. Manojit Pal |
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| Affiliation: | a New Drug Discovery, R&D Center, Matrix Laboratories Ltd, Anrich Industrial Estate, Bollaram, Jinnaram Mandal, Medak District, Andra Pradesh 502 325, India
b Department of Chemistry, University College of Science, Osmania University, Hyderabad 500 007, India |
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| Abstract: | The reactivity of the -C(Cl) C-CN- moiety towards an AlCl3-induced C-C bond forming reaction was investigated through the reaction of 7-chloro-5-phenyl-pyrazolo[1,5-a]pyrimidine with arenes and heteroarenes. This study furnished a novel and highly selective methodology for the preparation of 7-(hetero)aryl substituted-pyrazolopyrimidines in good to excellent yields under mild reaction conditions. |
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