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BF3·SiO2: an efficient reagent system for the one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles |
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| Authors: | Bahareh Sadeghi Mohammad M. Hashemi |
| Affiliation: | a Faculty of Chemistry, Islamic Azad University, Science and Research Branch, Tehran, Iran b Department of Chemistry, College of Science, Yazd University, Yazd, PO Box 89195-741, Iran c Department of Chemistry, Sharif University of Technology, PO Box 11365-9516, Tehran, Iran |
| Abstract: | Silica-supported boron trifluoride (BF3·SiO2) is an efficient, readily available and reusable catalyst for the synthesis of 1,2,4,5-tetrasubstituted imidazoles using benzil, an aromatic aldehyde and an amine in the presence of ammonium acetate. This one-pot procedure is very simple, affording good to excellent yields. |
| Keywords: | 1,2,4,5-Tetrasubstituted imidazoles BF3· SiO2 Benzil One-pot synthesis Aromatic aldehyde |
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