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BF3·SiO2: an efficient reagent system for the one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles
Authors:Bahareh Sadeghi  Mohammad M Hashemi
Institution:a Faculty of Chemistry, Islamic Azad University, Science and Research Branch, Tehran, Iran
b Department of Chemistry, College of Science, Yazd University, Yazd, PO Box 89195-741, Iran
c Department of Chemistry, Sharif University of Technology, PO Box 11365-9516, Tehran, Iran
Abstract:Silica-supported boron trifluoride (BF3·SiO2) is an efficient, readily available and reusable catalyst for the synthesis of 1,2,4,5-tetrasubstituted imidazoles using benzil, an aromatic aldehyde and an amine in the presence of ammonium acetate. This one-pot procedure is very simple, affording good to excellent yields.
Keywords:1  2  4  5-Tetrasubstituted imidazoles  BF3·  SiO2  Benzil  One-pot synthesis  Aromatic aldehyde
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