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Chemoenzymatic preparation of nucleosides from furanoses |
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| Authors: | Marisa Taverna-Porro Claudio A. Pereira Adolfo M. Iribarren |
| Affiliation: | a INGEBI (CONICET), Vuelta de Obligado 2490-(1428), Buenos Aires, Argentina b Instituto de Investigaciones Médicas Alfredo Lanari (CONICET-UBA), Av. Combatientes de Malvinas 3150 (1427), Cap. Fed., Argentina c Instituto de Ciencias, Universidad Nacional de Gral. Sarmiento, J. M. Gutierrez 1150, Los Polvorines (B1613GSX), Prov. de Bs. As., Argentina d Laboratorio de Biotransformaciones, Universidad Nacional de Quilmes, Roque Saenz Peña 352 (1876) Bernal, Prov. de Bs. As., Argentina |
| Abstract: | Chemoenzymatic preparation of ribose, deoxyribose and arabinose 5-phosphates was accomplished. These compounds were tested as starting materials in the enzymatic preparation of natural and modified purine and pyrimidine nucleosides, using an overexpressed Escherichia coli phosphopentomutase. |
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