Enantioselective total syntheses of ropivacaine and its analogues |
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| Authors: | Nagula Shankaraiah Leonardo S Santos |
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| Institution: | a Laboratory of Asymmetric Synthesis, Chemistry Institute of Natural Resources, Talca University, Talca, PO Box-747, Chile
b Instituto de Química, UNICAMP, PO Box 6154, 13083-970 Campinas, SP, Brazil |
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| Abstract: | An alternative asymmetric synthesis of ropivacaine and analogues employing the ‘cation pool’ strategy and host/guest supramolecular co-catalysis approach is presented. In this study, chiral auxiliaries, several soft nucleophiles as well as one-pot conditions for anodic oxidation, followed by nucleophilic addition, have been applied. |
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| Keywords: | Ropivacaine Levobupivacaine Anodic oxidation Cation pool Supramolecular complex |
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