Atropisomerism about a heptafluoroisopropyl to aryl bond in 5-amino-4-heptafluoroisopropyl indazole |
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| Authors: | Bahiya Atouioual Emmanuel Lamy Tammo Winkler |
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| Institution: | Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH-4332 Stein, Switzerland |
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| Abstract: | The atropisomerism about a heptafluoroisopropyl to aryl bond in 5-amino-4-heptafluoroisopropyl indazole is reported. The through-space hydrogen fluorine coupling of the indazole H-3 proton with the tertiary F atom is shown to be useful to distinguish the two rotamers. The same atropisomerism is also observed in the analogous indole, benzofuran, and naphthaline derivatives. |
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| Keywords: | Atropisomerism NMR Rotamers Heptafluoroisopropyl indazole |
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