De novo approach to l-anhydrohexitol nucleosides as building blocks for the synthesis of l-hexitol nucleic acids (l-HNA) |
| |
| Authors: | Daniele D&rsquo Alonzo,Arthur Van Aerschot,Giovanni Palumbo |
| |
| Affiliation: | a Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II, Via Cinthia, 4 I-80126 Napoli, Italy
b Katholieke Universiteit Leuven, Rega Institute for Medical Research, Minderbroederstraat 10, B-3000 Leuven, Belgium |
| |
| Abstract: | A stereoselective and scalable route to 1,5-anhydrohexitol nucleoside analogues belonging to l-series as building blocks for l-HNA oligonucleotide synthesis has been efficiently tuned. Key to the successful outcome of our approach is the development of a DDQ-mediated domino reaction, which leads to the formation of an unsaturated 1,6-anhydrosugar derivative. Sugar elaborations and base insertion then enable to synthesize six-membered nucleosides. |
| |
| Keywords: | 1,6-Anhydro- smallcaps" >l-sugars Domino reactions Nucleosides analogues HNA Oligonucleotides |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
