Ferrocene-based bidentate phosphonite ligands for rhodium(I)-catalyzed enantioselective hydroformylation |
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| Authors: | Xingao Peng Zheng Wang Kuiling Ding |
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| Institution: | a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, PR China
b State Key Laboratory of Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China |
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| Abstract: | A new class of chiral modular bidentate phosphonite ligands has been synthesized in good overall yields by using cheap trans-1,2-diaminocyclohexane and ferrocene as starting materials, and applied in the Rh(I)-catalyzed asymmetric hydroformylation of vinyl acetate and styrene to afford the corresponding optically active aldehydes with good regioselectivity (up to 16.9 b/l ratio) and moderate to good enantioselectivity (up to 83% ee). The substituents on the backbone of the ligands are found to exhibit a remarkable effect on both the regio- and enantioselectivity of the catalysis. |
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| Keywords: | Asymmetric catalysis Hydroformylation Bidentate ligand Phosphonite Rhodium |
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