Palladium-phosphinous acid-catalyzed cross-coupling of aliphatic and aromatic acyl chlorides with boronic acids |
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Authors: | Kekeli Ekoue-Kovi |
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Institution: | Department of Chemistry, Georgetown University, Washington, DC 20057, USA |
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Abstract: | The cross-coupling of aromatic and aliphatic acyl chlorides with arylboronic acids in the presence of 2.5 mol % of (t-Bu2POH)2PdCl2 (POPd) provides rapid access to ketones that are obtained in up to 93% yield. This palladium-phosphinous acid-catalyzed reaction is completed within 10 min when microwave irradiation is used, and it overcomes typical drawbacks of Friedel-Crafts acylation procedures such as harsh reaction conditions, untunable regiocontrol, and low substrate scope. |
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