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Selective debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate |
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| Authors: | Linna Zhou Wenjing Wang Li Zuo Wenhu Duan |
| Institution: | a Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China b Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People’s Republic of China c Department of Chemistry and Chemical Biology, University of New Mexico, Albuqueruqe, NM 87131-0001, USA |
| Abstract: | A new debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate is described. The process proceeds selectively and efficiently in good to excellent yields without affecting sensitive functional groups such as nitro, COOMe, aldehyde, ketone, and tosyl. |
| Keywords: | Aromatic benzyl ethers Debenzylation Silica-supported Sodium hydrogen sulfate |
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