Synthesis of a novel amphiphilic GdPCTA-[12] derivative as a potential micellar MRI contrast agent |
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| Authors: | Clotilde Ferroud,Hé lè ne Borderies,Elizabeth Lasri,Marc Port |
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| Affiliation: | a Laboratoire de Transformations Chimiques et Pharmaceutiques, UMR CNRS 7084, Conservatoire National des arts et métiers, Case 303, 2 rue Conté, 75003 Paris, France
b Guerbet, Centre de Recherche, BP 57400, 95943 Roissy CdG Cedex, France |
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| Abstract: | A novel amphiphilic contrast agent, a GdPCTA-[12] derivative containing a dodecyl chain as lipophilic moiety, has been prepared. A convergent synthetic route from commercially available diethylene triamine and 3-hydroxypyridine is described. The target amphiphilic gadolinium complex was obtained in nine steps in 22% overall yield. Physicochemical properties and relaxivity measurements of this new contrast agent are described. |
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| Keywords: | GdPCTA-[12] derivative Macrocyclic ligand Gadolinium Contrast agent MRI Amphiphilic Micelles |
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