Efficient synthesis of racemic β-aminophosphonates via aza-Michael reaction in water |
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| Authors: | Ekaterina V Matveeva |
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| Institution: | A.N.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova Street, 28, 119991 Moscow GSP-1, Russian Federation |
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| Abstract: | Water as a solvent significantly accelerates the addition of various amines to diethyl vinylphosphonate to yield β-aminophosphonates without any catalyst compared to known procedures for such aza-Michael reactions. The products are obtained in quantitative yields and high purity over short reaction times. Using a reactant ratio (vinylphosphonate/amine) of 2:1 resulted in double phosphorylation of primary amines. |
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| Keywords: | Amines Aza-Michael reaction Vinylphosphonate Water β-Aminophosphonates β-Aminophosphonic acid |
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