Photochemistry of 7-azide-1-ethyl-3-carboxylate-6,8-difluoroquinolone: a novel reagent for photoaffinity labeling |
| |
| Authors: | Elisa Leyva Denisse de Loera Socorro Leyva |
| |
| Institution: | Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Nava No. 6, San Luis Potosí, S.L.P. México 78210, Mexico |
| |
| Abstract: | A novel reagent for photoaffinity labeling, 7-azido-1-ethyl-3-carboxylate-6,8-difluoroquinolone, was obtained by nucleophilic substitution of 1-ethyl-3-carboxylate-6,7,8-trifluoroquinolone. Photochemical reaction of this azide with diethyl amine gave 7-hydrazino-derivative as the major product. This compound was generated by singlet nitrene N-H insertion. In addition, 7-amino-1-ethyl-3-carboxylate-6,8-difluoroquinolone was also obtained. |
| |
| Keywords: | Photochemistry Aryl azide Singlet nitrene Photoaffinity labeling Fluoroquinolone |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
