Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands |
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| Authors: | Teresa Semeraro Federico Corelli |
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| Institution: | Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, snc 53100 Siena, Italy |
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| Abstract: | A synthetic route for the preparation of 4,5-dihydro-3H-pyrrolo3,2-d]pyrimidin-4-ones characterized by a decorated benzyl moiety at different positions of the five-membered ring has been developed, and some compounds have been tested as Hsp90 ligands. One of them displayed IC50 = 50 μM representing an interesting starting point for further investigations. |
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| Keywords: | Hsp90 ligands Pyrrolo[3 2-d]pyrimidin-4-ones Deazapurines |
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