Structure determination and absolute configuration of cannabichromanone derivatives from high potency Cannabis sativa |
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Authors: | Safwat A. Ahmed Desmond Slade Ikhlas A. Khan Mahmoud A. ElSohly |
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Affiliation: | a National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA b Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA c Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA |
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Abstract: | Three new cannabichromanone derivatives were isolated from high potency cannabis, along with the known cannabichromanone. Full spectroscopic data, including the use of electronic circular dichroism and Mosher ester analysis to determine the absolute configuration of these compounds, are reported. All isolates were tested for antimicrobial, antimalarial, antileishmanial, and anti-oxidant activities. |
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Keywords: | Cannabis sativa Absolute configuration Cannabichromanone Circular dichroism Mosher ester analysis Antimicrobial Antimalarial Antileishmanial Anti-oxidant |
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