Highly efficient synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reactions in water |
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| Authors: | Hua Lin |
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| Institution: | Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China |
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| Abstract: | An efficient and simple method for the synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reaction of indoles with 2-formylbenzoic acids in pure water has been developed. The reaction affords a wide range of 3-indolyl-substituted phthalides in good to excellent yields. |
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