Synthesis of sterically-hindered peptidomimetics using 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride |
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| Authors: | Wen-Chung Shieh Zhuoliang Chen Song Xue Run-Ming Wang Oljan Repi? |
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| Affiliation: | a Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA
b Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA |
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| Abstract: | Our study demonstrated that 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride (DMTMM) is a versatile coupling reagent for the synthesis of sterically-hindered peptidomimetics. It is superior to HBTU/HOBt and CDMT in controlling racemization and N-arylation, respectively. |
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| Keywords: | 4-(4,6-Dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride DMTMM Sterically-hindered peptide synthesis Racemization control |
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