Microwave-assisted, Mo(CO)6-mediated, palladium-catalyzed amino-carbonylation of aryl halides using allylamine: from exploration to scale-up |
| |
| Authors: | Prasad Appukkuttan Erik Van der Eycken |
| |
| Affiliation: | a Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, PO Box 574, SE-751 23 Uppsala, Sweden
b Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium |
| |
| Abstract: | Palladium-catalyzed aminocarbonylations of various (hetero)aryl halides with allylamine using Mo(CO)6 as a solid, in situ CO source, were explored. Microwave-enhanced conditions proved to be highly useful in promoting the conversions in a mere 10-20 min with various (hetero)aryl iodides, bromides and chlorides. The scale-up of a microwave-enhanced aminocarbonylation to 25 mmol scale was performed successfully. |
| |
| Keywords: | Carbonylation Microwave Palladium Aryl chloride Scale-up |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
