Synthesis of spirocyclopentene-indolines by intramolecular alkylidine insertion reactions |
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| Authors: | Christopher J Whipp |
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| Institution: | Medicinal Chemistry, Chemistry Research and Development, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, United States |
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| Abstract: | Intramolecular 1,5 CH insertion of unstabilized carbenes into the tertiary carbon of a substituted indoline generates spirocyclopent2]ene-1,2′-indolines] in good yields and excellent enantioselectivities. |
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