A Ce(III)-catalyzed expeditious multicomponent stereoselective synthesis of 3-mercapto-2(1H)-pyridinones |
| |
Authors: | Lal Dhar S. Yadav Ritu Kapoor |
| |
Affiliation: | Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211 002, India |
| |
Abstract: | A novel Ce(III)-catalyzed, convenient, expeditious, and diastereoselective synthesis of 3-mercapto-2(1H)-pyridinones via one-pot, [3+2+1] three-component coupling reactions of chalcones, 2-methyl-2-phenyl-1,3-oxathiolan-5-one, and amines is reported. The synthesis involves sequential Michael addition, condensation, and ring transformation. Ambient temperature, operational simplicity, use of an environmentally clean catalyst, high yields, and diastereoselectivity are the key features of the present synthetic protocol. |
| |
Keywords: | Multicomponent reaction Lewis acid Chalcones 1,3-Oxathiolan-5-one 3-Mercapto-2(1H)-pyridinones Stereoselective synthesis |
本文献已被 ScienceDirect 等数据库收录! |
|