Three-component synthesis of 5:6 and 6:6 fused pyrimidines using KF-alumina as a catalyst |
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Authors: | Pushpak Mizar |
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Institution: | Department of Chemistry, North-Eastern Hill University, Mawlai-Mawkynroh, Shillong, Meghalaya 793 022, India |
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Abstract: | A series of fused pyrimidine derivatives were synthesized by the three-component reaction of an aryl aldehyde, urea, or guanidine in ethyl alcohol/dioxane in presence of 1-methyl-1H-pyrrol-2(3H)-one 1, 1-methylpiperidin-2-one 2, 1-methylindolin-2-one 3, or 1,3-dimethyl-dihydropyrimidine-2,4-dione 9 at 80 °C catalyzed by KF-Al2O3. For example, when 1-methyl-1H-pyrrol-2(3H)-one 1, arylaldehyde 4, and urea 5 were treated with KF-Al2O3 in ethyl alcohol at 80 °C for 3-5 h, we obtained pyrrolo2,3-d]pyrimidine derivatives in good yield. |
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