Multispectral optoacoustic tomography by means of normalized spectral ratio |
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| Authors: | Jetzfellner Thomas Rosenthal Amir Buehler Andreas Englmeier Karl-Hans Razansky Daniel Ntziachristos Vasilis |
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| Institution: | Institute for Biological and Medical Imaging, Technische Universit?t München and Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany. |
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| Abstract: | Quantification of biomarkers using multispectral optoacoustic tomography can be challenging due to photon fluence variations with depth and spatially heterogeneous tissue optical properties. Herein we introduce a spectral ratio approach that accounts for photon fluence variations. The performance and imaging improvement achieved with the proposed method is showcased both numerically and experimentally in phantoms and mice. |
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