Synthesis of 1,2,3-triazole linked galactopyranosides and evaluation of cholera toxin inhibition |
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Authors: | Leaver David J Dawson Raymond M White Jonathan M Polyzos Anastasios Hughes Andrew B |
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Institution: | Department of Chemistry, La Trobe University, Victoria, 3086, Australia. |
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Abstract: | We report the synthesis of a series of bivalent 1,2,3-triazole linked galactopyranosides as potential inhibitors of cholera toxin (CT). The inhibitory activity of the bivalent series was examined (ELISA) and the series showed low inhibitory activity (millimolar IC(50)s). Conversely, the monomeric galactotriazole analogues were strong inhibitors of cholera toxin (IC(50) = 71-75 μM). |
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