Quinoline-3-carboxamide derivatives as potential cholesteryl ester transfer protein inhibitors |
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| Authors: | Li Wen-Yan Xiong Xu-Qiong Zhao Dong-Mei Shi Yu-Fang Yang Zhi-Heng Yu Chao Fan Pei-Wei Cheng Mao-Sheng Shen Jing-Kang |
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| Institution: | Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China. |
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| Abstract: | A series of novel quinoline-3-carboxamide derivatives 10-17 and 23-27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%. |
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