首页 | 本学科首页   官方微博 | 高级检索  
     


Nanoprecipitation of Biocompatible Poly(malic acid) Derivative,Its Ability to Encapsulate a Molecular Photothermal Agent and Photothermal Properties of the Resulting Nanoparticles
Authors:Marian Gabriela Vargas Guerrero  Jean-Baptiste Pluta  Nathalie Bellec  Sandrine Cammas-Marion  Franck Camerel
Affiliation:1.Institut des Sciences Chimiques de Rennes (ISCR), Ecole Nationale Supérieure de Chimie de Rennes, CNRS, University of Rennes, UMR 6226, F-35042 Rennes, France; (M.G.V.G.); (J.-B.P.); (N.B.);2.Institut NUMECAN (Nutrition Metabolisms and Cancer), INSERM, INRAE, University of Rennes, UMR_A 1341, UMR_S 1241, F-35000 Rennes, France
Abstract:Biocompatible nanoparticles (NPs) of hydrophobic poly(benzyl malate) (PMLABe) were prepared by nanoprecipitation. The influence of nanoprecipitation parameters (initial PMLABe, addition rate, organic solvent/water ratio and stirring speed) were studied to optimize the resulting formulations in terms of hydrodynamic diameter (Dh) and dispersity (PDI). PMLABe NPs with a Dh of 160 nm and a PDI of 0.11 were isolated using the optimized nanoprecipitation conditions. A hydrophobic near infra-red (NIR) photothermally active nickel-bis(dithiolene) complex (Ni8C12) was then encapsulated into PMLABe NPs using the optimized nanoprecipitation conditions. The size and encapsulation efficiency of the NPs were measured, revealing that up to 50 weight percent (wt%) of Ni8C12 complex can efficiently be encapsulated with a slight increase in Dh of the corresponding Ni8C12-loaded NPs. Moreover, we have shown that NP encapsulating Ni8C12 were stable under storage conditions (4 °C) for at least 10 days. Finally, the photothermal properties of Ni8C12-loaded NPs were evaluated and a high photothermal efficiency (62.7 ± 6.0%) waswas measured with NPs incorporating 10 wt% of the Ni8C12 complex.
Keywords:biocompatible nanoparticles   poly(benzyl malate)   nanoprecipitation   metal-bis(dithiolene)   photothermal
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号