| 2-取代-3-N-酰基-5-氟-4-嘧啶酮的合成及其抗肿瘤活性 |
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| 引用本文： | 孙昌俊,李洪祥,李吉海,王义贵,戚聿新,张纪明,刘书银. 2-取代-3-N-酰基-5-氟-4-嘧啶酮的合成及其抗肿瘤活性[J]. 合成化学, 2000, 8(3): 248-251 |
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| 作者姓名： | 孙昌俊 李洪祥 李吉海 王义贵 戚聿新 张纪明 刘书银 |
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| 作者单位： | 1. 山东大学化学系,济南,250100
2. 枣庄师范专科学校化学系,枣庄,277160 |
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| 摘 要： | 在丙酮溶液中,于Et3N存在下使2-取代-5-氟-4-嘧啶酮与酰氯反应,合成了14个未见文献报道的2-取代-3-N-酰基-5-氟-4-嘧啶酮类化合物,它们的结构经IR,1HNMR,元素分析或MS确定.其中有些化合物具有一定的抗肿瘤活性.
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| 关 键 词： | 5－氟腺嘧啶 酰氯 合成 嘧啶酮 抗肿瘤活性 |
The Synthesis of 2-Substituted-3-acyl-5-fluoro-4-pyrimidones and Their Antitumor Activities |
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| Abstract. The Synthesis of 2-Substituted-3-acyl-5-fluoro-4-pyrimidones and Their Antitumor Activities[J]. Chinese Journal of Synthetic Chemistry, 2000, 8(3): 248-251 |
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| Authors: | Abstract |
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| Abstract: | Fourteen new 2-substituted-3-acyl-5-fluoro-4-pyrimidone compounds were prepared by the reaction of 2-substituted-5-fluoro-3H-4-pyrimidones with acyl chlorides in acetone in the presence of Et_3N. Their structures were confirmed by IR, 1H NMR and elementary analysis or MS. The preliminary antitumor tests showed that some of them exhibited certain activities. |
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| Keywords: | Fluorouracil Acyl chloride Antitumor compound Synthesis. |
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