| Synthesis and Crystal Structure of 3,3′-(Hexane-1,6-diyl)bis(1-acetyl-5,5-dimethylhydantoin),a New Inducer of Differentiation |
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| 引用本文： | SONG Xiang-Zhi LIU Guang SHEN Li-Chun ZHANG Shi-Wei (State Key Laboratory for Structural Chemistry of Unstable and Stable Species,Institute of Physical Chemistry,Peking University,Beijing 100871,China). Synthesis and Crystal Structure of 3,3′-(Hexane-1,6-diyl)bis(1-acetyl-5,5-dimethylhydantoin),a New Inducer of Differentiation[J]. 结构化学, 2002, 0(5) |
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| 作者姓名： | SONG Xiang-Zhi LIU Guang SHEN Li-Chun ZHANG Shi-Wei (State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Physical Chemistry Peking University Beijing 100871 China) |
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| 作者单位： | State Key Laboratory for Structural Chemistry of Unstable and Stable Species，Institute of Physical Chemistry，Peking University，Beijing 100871，China |
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| 基金项目： | This project was supported by the National Natural Science Foundation of China (No 39870983) |
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| 摘 要： | 1 INTRODUCTION Hexamethylenebis[acetamide] (HMBA) is an effective agent in phaseⅡclinical trial[1] that induces differentiation of certain types of tumors to nonmalignant phenotypes. In an attempt to discover more efficient inducers, a number of derivatives of HMBA have been synthesized and evaluated in vitro[2, 3]. The results proved that increasing the number of functional groups could enhance the anticancer activity. In addition, it was evident that compounds with six methylene i…
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Synthesis and Crystal Structure of 3,3′(Hexane-1,6-diyl)bis(1-acetyl-5,5-dimethylhydantoin), a New Inducer of Differentiation |
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| SONG Xiang-Zhi LIU Guang SHEN Li-Chun ZHANG Shi-Wei. Synthesis and Crystal Structure of 3,3′(Hexane-1,6-diyl)bis(1-acetyl-5,5-dimethylhydantoin), a New Inducer of Differentiation[J]. Chinese Journal of Structural Chemistry, 2002, 0(5) |
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| Authors: | SONG Xiang-Zhi LIU Guang SHEN Li-Chun ZHANG Shi-Wei |
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| Abstract: | The title compound (C20H30N4O6, Mr = 422.48) was synthesized and its crystal structure was determined by X-ray diffraction method. It crystallizes in the triclinic system, space group P with cell parameters: a = 8.330(2), b = 8.468(2), c = 16.017(3) ? ?= 97.30(3), ?= 92.33(3), ?= 103.94(3)? V = 1084.7(4) ?, Dc = 1.294 g/cm3, Z = 2, F(000) = 452 and ?= 0.096 mm-1. The structure was refined to R = 0.0483 for 3732 observed reflections with I > 2s(I) and wR = 0.1335 for 4828 unique reflections. The hydantoin rings are planar and the two ring planes of one molecule are paralleled to each other. |
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| Keywords: | HMBA anticancer activity cancer cell inducer of differentiation crystal structure |
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