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Photosynthesis and Molecular Structure of2—Amino—3H—phenoxazin—3—one
引用本文:聂晶晶,徐端钧. Photosynthesis and Molecular Structure of2—Amino—3H—phenoxazin—3—one[J]. 结构化学, 2002, 21(2): 165-167
作者姓名:聂晶晶  徐端钧
作者单位:Department of Chemistry,Zhejiang University,Hangzhou 310027,China
基金项目:The work was supported by the National Natural Science Foundation of China (29973036)
摘    要:1 INTRODUCTION 2-Amino-3H-phenoxazin-3-one (APX) is related to the naturally occurring antineoplastic actinomycin D and has been used as a chemical model of actinomycin D[1]. Usually APX is synthesized from 2-aminophenol with the phenoxazinone synthase in human body[2]. A variety of artificial synthesis methods of APX via the oxidation of 2-aminophenol have also been reported, but each method needs some artificial condition such as chemical catalysis[3~7], natural enzyme[8], UV…

关 键 词:2-氨基-3H-吩恶嗪-3-酮  分子结构  合成

Photosynthesis and Molecular Structure of 2-Amino-3H-phenoxazin-3-one
Abstract:The single crystal of the title compound (C12H8N2O2, Mr = 212.20) has been obtained by oxidation of 2-aminophenol in methanol solution with irradiation of sunlight. The crystal belongs to monoclinic space group P21/c with cell dimensions of a = 12.925(2), b = 5.077(3), c = 14.768(3)? b = 99.38(1), V = 956.2(5)?, Z = 4, Dc = 1.474 g/cm3, = 0.103 mm-1, R = 0.054, wR = 0.074 for 785 observed reflections (I > 2s(I)). The molecule consists of three coplanar rings. Much different CC distances (1.494(4)?and 1.343(6) ? observed within the quinoidal ring show the pattern of bond fixation expected for the Kekule formula.
Keywords:amino-3H-phenoxazin-3-one   photosynthesis   molecular structure   2-aminophenol
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