Photosynthesis and Molecular Structure of2—Amino—3H—phenoxazin—3—one |
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引用本文: | 聂晶晶,徐端钧. Photosynthesis and Molecular Structure of2—Amino—3H—phenoxazin—3—one[J]. 结构化学, 2002, 21(2): 165-167 |
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作者姓名: | 聂晶晶 徐端钧 |
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作者单位: | Department of Chemistry,Zhejiang University,Hangzhou 310027,China |
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基金项目: | The work was supported by the National Natural Science Foundation of China (29973036) |
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摘 要: | 1 INTRODUCTION 2-Amino-3H-phenoxazin-3-one (APX) is related to the naturally occurring antineoplastic actinomycin D and has been used as a chemical model of actinomycin D[1]. Usually APX is synthesized from 2-aminophenol with the phenoxazinone synthase in human body[2]. A variety of artificial synthesis methods of APX via the oxidation of 2-aminophenol have also been reported, but each method needs some artificial condition such as chemical catalysis[3~7], natural enzyme[8], UV…
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关 键 词: | 2-氨基-3H-吩恶嗪-3-酮 分子结构 合成 |
Photosynthesis and Molecular Structure of 2-Amino-3H-phenoxazin-3-one |
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Abstract: | The single crystal of the title compound (C12H8N2O2, Mr = 212.20) has been obtained by oxidation of 2-aminophenol in methanol solution with irradiation of sunlight. The crystal belongs to monoclinic space group P21/c with cell dimensions of a = 12.925(2), b = 5.077(3), c = 14.768(3)? b = 99.38(1), V = 956.2(5)?, Z = 4, Dc = 1.474 g/cm3, = 0.103 mm-1, R = 0.054, wR = 0.074 for 785 observed reflections (I > 2s(I)). The molecule consists of three coplanar rings. Much different CC distances (1.494(4)?and 1.343(6) ? observed within the quinoidal ring show the pattern of bond fixation expected for the Kekule formula. |
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Keywords: | amino-3H-phenoxazin-3-one photosynthesis molecular structure 2-aminophenol |
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