| Crystal Structure and Conformation of [1-(β-D-lyxofuranosyl)uracil]- 2'-spiro-5"-[4"-(S)-(diethoxyphosphinyl)-2"-oxazoline] |
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| 引用本文： | CHI Guo-Chen②,CHEN Ru-Yu②.Crystal Structure and Conformation of [1-(β-D-lyxofuranosyl)uracil]- 2''''-spiro-5"-[4"-(S)-(diethoxyphosphinyl)-2"-oxazoline][J].结构化学,2002(1). |
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| 作者姓名： | CHI Guo-Chen② CHEN Ru-Yu② |
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| 作者单位： | CHI Guo-Chen② CHEN Ru-Yu② (Institute and National Key Laboratory of Elemento-Organic Chemistry，Nankai University，Tianjin 300071，China) WANG Hong-Gen YAO Xin-Kan (Central Laboratory，Nankai University，Tianjin，300071，China) |
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| 基金项目： | This project was supported by the Foundation for University Key Teachers by the Ministry of Education |
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| 摘 要： | 1 INTRODUCTION It is well known that natural and modified nucleosides have potential antiviral and anticancer activities1,2]. These observations prompted us to synthesize the title compound －a new kind of spironucleoside, whose structure was determined by 1HNMR, 31PNMR and elemental analysis. The configuration was assigned by means of nuclear Overhauser effect. To further confirm the structure and configuration unambiguously, the title compound was subjected to X-ray diffractio…
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