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Regio-selective synthesis of 1,2-aminoalcohols from epoxides and chlorohydrins |
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| Authors: | Andiappan Murugan Vasantha Krishna KadambarSreekanth Bachu M Rajashekher ReddyVenkatarao Torlikonda Sulur G ManjunathaSridharan Ramasubramanian Sudhir NambiarGareth P Howell Jane Withnall |
| Institution: | a AstraZeneca India Pvt. Ltd, Off Bellary Road, Bangalore 560024, India b AstraZeneca, Charter way, Silk Road Business Park, Macclesfield, Cheshire SK10 2NX, UK |
| Abstract: | A simple and efficient procedure for the regio-selective synthesis of 1,2-aminoalcohols from terminal epoxides and chlorohydrins by using NaHMDS as the source of amine is reported. The wider scope and utility of this method is demonstrated. |
| Keywords: | 1 2-Aminoalcohol Epoxide Chlorohydrin NaHMDS Epoxide opening Regio-selective |
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