Enantiospecific enzymatic synthesis of N-carbamoyl-d-p-fluorophenylglycine and N-carbamoyl-d-p-trifluoromethylphenylglycine

Enantiospecific enzymatic hydrolysis of rac-5-arylhydantoins is described. Immobilized d-hydantoinase from Vigna angularis was used to produce with 100% conversion and over 98% enantiomeric excess N-carbamoyl-d-p-fluorophenylglycine and N-carbamoyl-d-p-trifluoromethylphenylglycine.