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Uncatalyzed Meerwein-Ponndorf-Verley reduction of trifluoromethyl carbonyl compounds by high-temperature secondary alcohols |
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| Authors: | Sergei A. Lermontov Sergei V. Shkavrov Nina V. Kuryleva |
| Affiliation: | Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region 142432, Russia |
| Abstract: | Noncatalytic Meerwein-Ponndorf-Verley (MPV) reduction of hexafluoroacetone and methyl ester of trifluoropyruvic acid into hexafluoroisopropanol (HFIP) and trifluorolactic esters, respectively can be achieved by heating with secondary alcohols at 210-250 °C without any catalyst. |
| Keywords: | Hexafluoroacetone Hexafluoroisopropanol Methyl trifluoropyruvate Trifluorolactic esters Meerwein-Ponndorf-Verley (MPV) reduction High-temperature alcohols |
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