Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives |
| |
| Authors: | Kazuto Umezu |
| |
| Institution: | Research and Development Department, Ihara Chemical Industry Co. Ltd., Fujikawa-cho, Ihara-gun, Shizuoka 421-3306, Japan |
| |
| Abstract: | Ortho-substituted fluorine in 2,4-difluorobenzoic acid was found to be regio-selectively replaced to hydroxide by solid sodium hydroxide in 1,3-dimethyl-2-imidazolidinone, to afford 4-fluoro-2-hydroxybenzoic acid in high yield. Several multi-fluoro-substituted benzoic acid derivatives were effectively transformed to the corresponding salicylic acid derivatives under the similar conditions. |
| |
| Keywords: | Ortho-substitution 2 4-Difluorobenzoic acid 4-Fluoro-2-hydroxybenzoic acid Solid sodium hydroxide |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
