Synthesis of fluorinated materials catalyzed by proline or antibody 38C2 in ionic liquid |
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| Authors: | Tomoya Kitazume Zaiju Jiang Kana Kasai Yuma Mihara Mamie Suzuki |
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| Affiliation: | Graduate School of Biosceince & Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan |
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| Abstract: | The utility of reusable ionic liquid-proline (or aldolase antibody 38C2) reaction system, proceeding the aldol reactions, is described. Further, obtained α-chloro-β-hydroxy compounds were transformed to the optically active α,β-epoxy carbonyl compounds. The aldolase antibody 38C2-ionic liquid system was able to reuse in Michael additions and the reaction of fluoromethylated imines. |
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| Keywords: | Aldolase antibody Aldol reaction Michael addition reaction |
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