| Application of the Reversed-phase Liquid Chromatography Coupled to Ion Trap Mass Spectrometry with Principal Components Analysis for Metabonomics Studies of Scutellarin in Rat Urine |
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| 作者姓名： | Xiao Rong RAN Sheng Zhu SI Qiong Lin LIANG Guo An LUO |
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| 作者单位： | Xiao Rong RAN1，Sheng Zhu SI1，2，Qiong Lin LIANG1，Guo An LUO1* 1 Department of Chemistry，Tsinghua University，Beijing 100084 2 Anhui Institution of Education，Hefei 230061 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | Recently, much attention has been paid to metabonomics and great growth in it as a novel systemic approach to study metabolic profile accelerate the process of drug development1-5. Traditional Chinese Medicine (TCM) is an emerging field for medical and ph…
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| 关 键 词： | LC/MS 黄芩素 代谢物 内生 反相液相色谱法 化学分析 中药 |
| 收稿时间： | 2006-03-24 |
Application of the Reversed-phase Liquid Chromatography Coupled to Ion Trap Mass Spectrometry with Principal Components Analysis for Metabonomics Studies of Scutellarin in Rat Urine |
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| Xiao Rong RAN Sheng Zhu SI Qiong Lin LIANG Guo An LUO.Application of the Reversed-phase Liquid Chromatography Coupled to Ion Trap Mass Spectrometry with Principal Components Analysis for Metabonomics Studies of Scutellarin in Rat Urine[J].Chinese Chemical Letters,2006,17(9):1225-1228. |
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| Authors: | Xiao Rong RAN Sheng Zhu SI Qiong Lin LIANG Guo An LUO |
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| Abstract: | Metabonomics, a novel systemic approach, was applied to studies of Traditional Chinese Medicine scutellarin in rat urine. The liquid chromatography coupled with ion trap mass spectrometry combined with PCA was used in this paper. With this methodology, two potential metabolites of scutellarin were detected and the nine ions responsible for the gender variation and one ion for the dosage variation were found. |
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| Keywords: | Metabonomics LC/MS scutellarin metabolites endogenous |
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