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Design and synthesis of novel dinucleotide analogs |
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| Authors: | F Valiyev V Abbasov H J Liu F Y Tsai |
| Institution: | 1. Institute of Chemistry, Academia Sinica, Taipei, 115, Taiwan 3. Institute of Petrochemical Processes of Azerbaijan NAS, Baku, Azerbaijan 2. Department of Chemistry, National Tsing Hua University, Hsinchu, 300, Taiwan 4. Center for General Education, Chang Gung University, Tao-Tuan, 333, Taiwan |
| Abstract: | Syntheses of dinucleotide analogs, (S,R) cis-(4-((4-amino-2-oxopyrimidin-1(2H)-yl)methyl)-1,3-dioxolan-2-yl)methyl (2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl hydrogen phosphate (5a) and (S,R) cis-(5-((4-amino-2-oxopyrimidin-1(2H)-yl)methyl)-1,3-oxathiolan-2-yl)methyl (2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl hydrogen phosphate (5b), were accomplished by the use of a new strategy. The use of phenyldichlorophosphate (Method A) as the coupling reagent was shown to possess superiority relative to the reported use of di(1H-benzod]1,2,3]triazol-1-yl)phenyl phosphonate (Method B). |
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