Saccharin sulfonic acid catalyzed N-Boc protection of amines and formation of tert-butyl ethers from alcohols |
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| Authors: | F. Shirini M. A. Zolfigol M. Abedini |
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| Affiliation: | 1. Department of Chemistry, College of Science, University of Guilan, Rasht, 41335, I. R. Iran
2. College of Chemistry, Bu-Ali Sina University, Hamadan, I. R. Iran
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| Abstract: | Saccharin sulfonic acid (SaSA), as a stable reagent is easily prepared by the reaction of saccharin with neat chlorosulfonic acid at room temperature. This compound is able to catalyze conversion of amines to their corresponding N-Boc protected amines with (Boc)2O. Alcohols were also converted to their corresponding tert-butyl ethers. All reactions took place under mild conditions giving the desired products in good to high yields. |
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