A novel and efficient approach for the amidation of C-terminal peptides |
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Authors: | A Arabanian M Mohammadnejad S Balalaie |
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Institution: | 1. Peptide Chemistry Research Center, K.N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran
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Abstract: | A highly efficient and practical synthesis of C-terminal amidated peptides has been developed. According to this approach, amidation of the C-terminus of peptides was carried out using NH4Cl, alkylammonium chloride (RNH3Cl) and semicarbazide hydrochloride in the presence of TBTU as a coupling reagent and a tertiary amine as the base at room temperature in good to high yields. Some opioid peptides such as enkephalin derivatives were synthesized according to this novel method. |
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