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Synthesis and absolute configuration of A-factor,the inducer of streptomycin biosynthesis in inactive mutants of Streptomyces griseus
Authors:Kenji Mori
Institution:Department of Agricultural Chemistry, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan
Abstract:The absolute configuration at C-3 of A-factor, 2-(6-methylheptanoyl)-3-hydroxymethyl-4-butanolide 1a, was determined to be S by synthesizing(3S)-(+)-A-factor.
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