| 液相色谱-电喷雾串联质谱法测定禽类产品中克球酚的残留 |
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| 引用本文： | 杨雯筌,徐锦忠,杨功俊,丁涛,齐涓菲,柳菡,沈崇钰,吴斌,余枢.液相色谱-电喷雾串联质谱法测定禽类产品中克球酚的残留[J].色谱,2009,27(2):144-148. |
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| 作者姓名： | 杨雯筌 徐锦忠 杨功俊 丁涛 齐涓菲 柳菡 沈崇钰 吴斌 余枢 |
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| 作者单位： | 1.Laboratory of Food, Jiangsu Entry-Exit Inspection and Quarantine Bureau, Nanjing 210001, China; 2.School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225009, China |
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| 摘 要： | 建立了禽类产品中克球酚残留的液相色谱-电喷雾串联质谱(LC-ESI-MS/MS)检测方法。用甲醇对样品进行提取,提取液用正己烷萃取去油脂,然后用LC-18柱和阴离子交换柱净化,LC-ESI-MS/MS测定。利用基质校正曲线对克球酚准确定量。在2,5,10,20 μg/kg 4个添加水平下,克球酚的平均回收率稳定在55.38%～132.44%之间,日内精密度小于9.54%,日间精密度小于15.27%。在1～40 μg/kg范围内色谱峰面积与克球酚含量呈良好的线性关系,检出限为0.5 μg/kg，定量限为2.0 μg/kg。该方法选择性好,抗干扰能力强,可作为禽类产品中克球酚残留检测的确证方法。
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| 关 键 词： | 固相萃取 基质效应 克球酚 禽类产品 液相色谱-电喷雾串联质谱联用 |
| 收稿时间： | 2008-8-25 |
| 修稿时间： | 2008-10-25 |
Determination of clopidol residue in poultry products by liquid chromatography-electrospray ion trap tandem mass spectrometry |
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| YANG Wenquan,XU Jinzhong,YANG Gongjun,DING Tao,QI Juanfei,LIU Han,SHEN Chongyu,WU Bin,YU Shu.Determination of clopidol residue in poultry products by liquid chromatography-electrospray ion trap tandem mass spectrometry[J].Chinese Journal of Chromatography,2009,27(2):144-148. |
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| Authors: | YANG Wenquan XU Jinzhong YANG Gongjun DING Tao QI Juanfei LIU Han SHEN Chongyu WU Bin YU Shu |
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| Institution: | 1.Laboratory of Food, Jiangsu Entry-Exit Inspection and Quarantine Bureau, Nanjing 210001, China; 2.School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225009, China |
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| Abstract: | A method is presented for the determination of clopidol residue in poultry products by liquid chromatography-electrospray ion trap tandem mass spectrometry(LC-ESI-MS/MS).Clopidol residue was extracted with methanol and cleaned-up by n-hexane from different poultry products.The extract was cleaned-up by an LC-18 column and an ion exchange solid phase extraction(SPE) column.Quantification was achieved by matrix calibration.The recoveries of clopidol in poultry products were in the range from 55.38% to 132.44%... |
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| Keywords: | liquid chromatography-electrospray ion trap tandem mass spectrometry (LC-ESI-MS/MS) solid phase extraction (SPE) clopidol poultry products matrix effect |
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