054 Determination of clarithromycin and its R-14-hydroxy-metabolite in human serum and urine by reversed-phase HPLC and electrochemical detection |
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| Authors: | K Borner H Hartwig and H Lode |
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| Institution: | (1) Institute for Clinical Chemistry and Clinical Biochemistry, Klinikum Steglitz, W-1000 Berlin 45, Federal Republic of Germany;(2) Pneumological Department I, City-Hospital Zehlendorf-Heckeshorn, Free University Berlin, W-1000 Berlin 39, Federal Republic of Germany |
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| Abstract: | Summary Clarithromycin and its main metabolite R-OH-clarithromycin are determined in human serum and urine. The method is based on liquid-liquid extraction, reversed-phase chromatography and dual-mode coulometric detection. The method is fairly selective. No interferences were observed in samples from human volunteers. Detection limits were 0.05 mg/l serum and 1.3 mg/l urine. |
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