Recent progress in the development of derivatization reagents having a benzofurazan structure |
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| Authors: | Santa Tomofumi Fukushima Takeshi Ichibangase Tomoko Imai Kazuhiro |
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| Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. santa@mol.f.u-tokyo.ac.jp |
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| Abstract: | Chemical derivatization is often used to enhance the detectability of the target compounds and to improve the separation efficiency in high-performance liquid chromatography (HPLC). In this review, we describe the recent progress in the development of derivatization reagents having a benzofurazan structure, namely, the fluorogenic reagents, water-soluble reagents, reagents for the analysis of peptides and proteins, and reagents for mass spectrometric detection. The application of these reagents to bio-samples is also briefly described. |
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| Keywords: | benzofurazan 2 1 3‐benzoxadiazole derivatization reagent fluorescence mass spectrometry high‐performance liquid chromatography |
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